Glycochenodeoxycholic acid

Name: Glycochenodeoxycholic acid
Brand: Selleck Chemicals
SKU: S5794
Rating: 5 (1 reviews)

Synonyms: Glycochenodeoxycholate, Chenodeoxycholylglycine, Glycine chenodeoxycholate

Catalog No.S5794 Purity:99.35%

Glycochenodeoxycholic acid (Glycochenodeoxycholate, Chenodeoxycholylglycine, Glycine chenodeoxycholate) is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption. Glycochenodeoxycholic acid

Glycochenodeoxycholic acid Chemical Structure

CAS No. 640-79-9

Purity & Quality Control

Batch: S579401 DMSO]90 mg/mL]false]Ethanol]90 mg/mL]false]Water]Insoluble]false Purity: 99.35%

99.35

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Biological Activity

Description	Glycochenodeoxycholic acid (Glycochenodeoxycholate, Chenodeoxycholylglycine, Glycine chenodeoxycholate) is a bile salt formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption. Glycochenodeoxycholic acid

In vitro
In vitro	Glycochenodeoxycholic acid promotes chemoresistance in HCC cells by down-regulating and up-regulating the expression of apoptotic and anti-apoptotic genes, respectively. Furthermore, Glycochenodeoxycholic acid induces the EMT phenotype and stemness in HCC cells and activated the STAT3 signaling pathway. ^[1]
Cell Research	Cell lines	hepatocellular carcinoma (HCC) cell lines
	Concentrations	200 μM
	Incubation Time	24 h
	Method	HCC cells are treated with Glycochenodeoxycholic acid and chemotherapeuticdrugs5-fluorouracil (5-FU) (120μg/mL) and cisplatin (10 μg/mL), and the cell viability is detected using the CCK-8 assay.

In Vivo
In vivo	Glycochenodeoxycholic acid exerts effects on hypothalamic CRH expression after their uptake through the apical sodium-dependent bile acid transporter and subsequent activation of the glucocorticoid receptor.

References

[1] Shi C, et al. Aging (Albany NY). 2020 Aug 3;12(15):15546-15555.

Chemical Information & Solubility

Molecular Weight	449.62	Formula	C₂₆H₄₃NO₅
CAS No.	640-79-9	SDF	--
Smiles	CC(CCC(=O)NCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 90 mg/mL ( (200.16 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 90 mg/mL

Water : Insoluble

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In vivo
Batch:

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In vivo Formulation Calculator

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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